Yes, but the good thing is you can reload your manage without rebooting server;
@reloadmanage.
nop but like jealy said saved alot of hassle of rebooting if you already have people playing on your server
actually qmanage gets check each time you log in while qfunction is always active .. lets say if u put a ranking system in qmanage and you are ingame and level to a new ranking you will not get the ranking until u dont log out and in.. while if u had the ranking script in qfunction u will get the ranking just after you level yup..